The next generation of scientists will need to have a broad base of skills; no individual with training in a single discipline will solve any of the coming challenges that we face. Our group looks at a broad range of problems and we collectively design solutions working in collaboration with groups through the university, academia and industry. We also seek solutions that have some practical endpoint, to see that our work will some day be useful. And we work with students of all ages, from the very young to the very old.
C U R R E N T R E S E A R C H
Two areas currently attract our attention. In close collaboration with the Ludwig Institute for Cancer Research we are pursuing the development of therapeutic agents for the treatment of cancer. To reach this goal we have just completed the construction of a GMP Bioproduction Facility, the only one in existence in an academic setting in the U.S. We are also applying the tools and the processes of nanofabrication to create a new generation of sensors and other tiny devices.
I N T E R E S T S / W O R K I N P R O G R E S S
What we do:
Development and implement processes for the recombinant production of therapeutic proteins
Explore the use of nanoscale materials inspired by biological systems.
Design and create novel biosensors.
Create hands-on science for young students and engage them in thinking about how cool it is to be a scientist.
E D U C A T I O N
B.S., Microbiology, Kansas State University M.S., Food Science, Rutgers University Ph.D., Food Science, Rutgers University
S E L E C T E D P U B L I C A T I O N S
Joosten, C.E., Cohen, L.S., Ritter, G, Batt, C.A. and Shuler, M.L. (2004) Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. Biotechnol. Prog. 20:1273-1279.
Damasceno, L.M., Pla, I., Chang, H.J., Cohen, L., Ritter, G., Old L.J., Batt. C.A. (2004) An optimized fermentation process for high-level production of a single-chain Fv antibody fragment in Pichia pastoris. Protein Expr. Purif. 37:18-26.
Mark S.S., Sandhyarani, N., Zhu, C., Campagnolo, C., Batt C.A. (2004) Dendrimer-functionalized self-assembled monolayers as a surface plasmon resonance sensor surface. Langmuir. 20:6808-6817.
Campagnolo, C., Meyers, K.J., Ryan, T, Atkinson, R.C., Chen, Y-T., Scanlan, M.J., Ritter, G., Old, L.J. and Batt. C.A. (2004) Real-time label-free monitoring of tumor antigen and serum antibody interactions. J. Biochem. Biophy. Meth. 61: 283-298.
Niamsiri, N., Delamarre, S.C., Kim, Y.R. and Batt, C.A. (2004) Engineering of chimeric class II polyhydroxyalkanoate synthases. Appl. Environ. Microbiol. 70:6789-6799.
Shah, D., Maiti, P., Gunn, E., Schmidt, D.F., Jiang, D.D., Batt, C.A. and Giannelis, E.P. (2004) Dramatic enhancements in toughness of polyvinylidene fluoride nanocomposites via nanoclay-directed crystal structure and morphology. Adv. Mater. 16: 1173-1177.
Tyner, K.M., Roberson, M.S., Berghorn, K.A. Li, L., Gilmour, R.F., Batt, C.A. and Giannelis, E.P. (2004) Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids. J. Control. Release 100: 399-409.
Shah, D., Maiti, P., Jiang, D.D., Batt, C.A. and Giannelis, E.P. (2005) Effect of nanoparticle mobility on toughness of polymer composites. Adv. Material. 17: 525-528.
Paik, H-J., Kim, Y.R., Orth, R.N., Ober, C.K., Coates, G.W. and Batt, C.A. (2005) End functionalization of poly (3-hyrdroxybutyrate) via genetic engineering for solid surface modification. Chem. Commun. 15: 1956-58.
Stelick, S.J., Alger, W.H., Laufer, J.S., Waldron, AM., and Batt, C.A. (2005) Hands-on classroom photolithography laboratory to explore nanotechnology J. Chem. Educ. 82: 1361-1364.
Delamarre, S.C., Chang, H-Y and Batt, C.A. (2005) Identification and characterization of two polyhydroxyalkanoate biosynthesis loci in Pseudomonas sp. Strain 3Y2. Appl. Microbiol. Biotechnol. 69 293-303.
Cady, N.C., Stelick, S., Kunnavakkam, M.V. and Batt, C.A. (2005) Real-time PCR detection of Listeria monocytogenes using an integrated microFLUIDICS platform. Sens. Actuators. B 107, 332-341.
Delamarre, S.C. and Batt, C.A. (2005) Comparative study of promoters for the production of polyhydroxyalkanoates in recombinant strains of Wautersia eutropha. Appl. Microbiol. Biotechnol.2006 Aug;71 (5):668-79. Epub 2005 Dec 15.
Kim, Y-R., Paik, H-j., Ober, C.K., Coates, G.W., Mark, S.S., Ryan, T.E. and Batt, C.A. (2006) Real-time analysis of enzymatic surface initiated polymerization using surface plasmon resonance (SPR). Macromol. Biosci. 6: 145-152.
Bhatnagar, P., Mark, S.S., Kim, I., Chen, H., Schmidt, B., Lipson, M. and Batt, C.A. (2005) Dendrimer-scaffold-based electron-beam patterning of biomolecules. Adv. Material. 18 315-319. Mark, S.S., Bergkvist, M., Yang, X., Teixeira, L.M., Bhatnagar, P., Angert, E.R. and Batt, C.A. (2006) Bionanofabrication of metallic and semiconductor nanoparticles arrays using S-layer protein lattices with different lateral spacings. Langmuir.2006 Apr 11;22(8):3763-3774.
Pla, I.A., Damasceno, L.M., Vannelli, T., Ritter, G., Batt, C.A. and Shuler, M.L. (2006) Evaluation of Mut+ and MutS Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration. Biotechnol. Prog.2006 May-June;22(3):881-888.
Waldron, A.M., Spencer, D. and Batt, C.A. (2006) The current state of public understanding of nanotechnology. J. Nanoparticle Res.8, 569-575.
Cady, N.C., Strickland, A.D. and Batt, C.A. (2006) Optimized linkage and quenching strategies for quantum dot molecular beacon. Mol. Cell. Probes;21(2):116-24.
Damasceno, L.M., Anderson, K.A., Ritter, G., Cregg, J.M., Old, L.J. and Batt, C.A. (2006) Cooverexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris. Appl. Microbiol. Biotechnol. DOI 10.1007/s00253-006-0652-7. 74(2): 381-389.